Resource Summary

Clinical Question:
Do proton pump inhibitors (PPIs) interact with clopidogrel to reduce its cardiovascular (CV) benefit?

Studies are inconsistent about the impact of PPIs on clopidogrel effectiveness^ though most higher-quality studies show no interaction. The association with CV risk seen with PPI use is likely due to underlying comorbidities rather than a true drug interaction.

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Publication Date: 2013-10-7
Last Updated on PCR: 2017-07-07 19:53:06