Resource Summary

Clinical Question:
In the prevention or prophylaxis of headaches (including migraines)^ which antidepressants work and how effective are they?

Bottom-line:
Daily tricyclic antidepressants^ particularly amitriptyline^ effectively reduce headache severity and frequency. They are effective regardless of headache type and the benefit improves with time.


*** Original Documents can be found and downloaded using the link provided below ***

https://www.acfp.ca/tools-for-practice/

Publication Date: 2015-4-30
Last Updated on PCR: 2017-03-31 15:22:51