Resource Summary

Clinical Question:
In the prevention or prophylaxis of headaches (including migraines)^ which antidepressants work and how effective are they?

Daily tricyclic antidepressants^ particularly amitriptyline^ effectively reduce headache severity and frequency. They are effective regardless of headache type and the benefit improves with time.

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Publication Date: 2015-4-30
Last Updated on PCR: 2017-03-31 15:22:51