Resource Summary

Clinical Question:
When choosing a thiazide diuretic for hypertension^ is hydrochlorothiazide (HCTZ) the best choice?

The available data suggest that chlorthalidone is at least equal to and very likely superior to HCTZ in reducing BP and improving clinical outcomes. Consider prescribing chlorthalidone (12.5mg increasing to 25mg daily) when initiating thiazide diuretic therapy for hypertension.

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Publication Date: 2012-2-6
Last Updated on PCR: 2017-03-31 16:07:06