Resource Summary

Clinical Question:
Does smoking cessation with varenicline (Champix) increase the risk of cardiovascular disease (CVD)?

Varenicline may increase cardiovascular events^ however^ (if real) the absolute risks are low (<1 in 600) for low CVD risk patients and higher (perhaps 1 in 60) for patients with CVD. Smoking cessation should always be encouraged^ but patients with high risk of cardiovascular disease should understand the potential risks of varenicline and may wish to consider alternative therapies.

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Publication Date: 2012-8-13
Last Updated on PCR: 2017-03-31 16:58:09