Resource Summary

Clinical Question:
Which drug lowers blood pressure (BP) best in patients with resistant hypertension?

Bottom-line:
Spironolactone provides the largest BP reduction for “4th line therapy” in resistant hypertension (10/4 mmHg)^ causing an additional one in every three patients treated to reach target. Potassium rises on average -0.4 mmol/L (and should be monitored)^ causing around 2 percent to stop due to hyperkalemia (≥5.5 mmol/L). Hard outcome data is lacking.


*** Original Documents can be found and downloaded using the link provided below ***

https://www.acfp.ca/tools-for-practice/

Publication Date: 2016-6-20
Last Updated on PCR: 2017-03-31 16:53:47