Resource Summary

Clinical Question:
Are antipsychotics^ either added to standard antidepressants or as monotherapy^ effective for the treatment of depression without psychotic features?

Second-generation antipsychotics appear effective in treating depression when given to augment antidepressants. One antipsychotic (quetiapine) appears effective in treating depression alone but equivalence to antidepressants is uncertain. The evidence has a high risk of bias and adverse events are common.

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Publication Date: 2012-1-23
Last Updated on PCR: 2017-03-31 15:25:45