Resource Summary

Clinical Question:
Does digoxin change clinical outcomes for patients with congestive heart failure or atrial fibrillation?
For systolic congestive heart failure (CHF)^ a randomized controlled trial (RCT) demonstrated that digoxin decreases CHF related hospitalizations (for one in 13 patients) without altering mortality. Stopping digoxin in stable CHF patients may worsen symptoms. Post-hoc analysis suggests low serum digoxin levels may actually decrease mortality. Cohort data for atrial fibrillation (AF) or CHF suggests digoxin increases mortality^ although cause and effect is not established.

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Publication Date: 2015-5-25
Last Updated on PCR: 2017-03-31 14:53:28