Resource Summary

Clinical Question:
What is the risk of electrolyte disturbances with diuretics and ACE Inhibitors and when should we check?

Moderate hyponatremia (Na <130 mmol/L) and hypokalemia (K <3.2 mmol/L) each occur in -4 percent of thiazide users^ and hyperkalemia (K >5.4 mmol/L) occurs in 4 percent of ACE inhibitor (and angiotensin receptor blocker) users. Limited evidence suggests checking electrolytes in the first 2-4 weeks after starting^ and again after increasing doses of these agents^ and at least annually thereafter.

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Publication Date: 2016-5-24
Last Updated on PCR: 2017-03-31 16:01:15