Resource Summary

Clinical Question:
What is the safety and efficacy of doxylamine/pyridoxine (Diclectin) in nausea and vomiting of pregnancy?

Bottom Line:
Doxylamine/B6 appears safe short-term and may be slightly better than placebo in reducing nausea and vomiting in pregnancy (~1 point better on 15-point scale). B6 alone may have similar effect on nausea but other effects unclear. Results are at high risk of bias due to initially undeclared industry support and methodological concerns.

Publication Date: 2017-5-1
Last Updated on PCR: 2017-05-31 21:34:44