Resource Summary

Clinical Question:
In patients with coronary heart disease (like previous myocardial infarction)^ what are the benefits and harms of prescribing high dose compared to low dose statins?

Bottom-line:
In patients with coronary heart disease^ using high dose statins (compared to low-moderate dose) prevents one CHD event for every 91 patients but results in one in 47 patients discontinuing therapy due to adverse events. However^ low-moderate dose statin (compared to placebo) provides 2-3 times greater benefit than increasing to high dose statin. Therefore^ getting and keeping patients on any statin is key^ with dose adjusted up to tolerable levels.


*** Original Documents can be found and downloaded using the link provided below ***

https://www.acfp.ca/tools-for-practice/

Publication Date: 2012-5-22
Last Updated on PCR: 2017-03-31 15:58:45