Resource Summary

Clinical Question:
Does getting to target/higher doses of heart failure (HF) medications improve outcomes and/or increase side effects?

In HF patients^ higher dose angiotensin-converting enzyme (ACE) inhibitors^ beta-blockers^ and angiotensin receptor blockers (ARB) versus lower doses result in non-significant improvements in mortality^ and inconsistent decreases in HF hospitalizations. Higher doses cause more dizziness or hypotension (4-15 percent)^ dose reductions (20 percent)^ and stopping (2-8 percent). Starting on low doses and focusing on tolerability is essential.

Publication Date: 2016-11-1
Last Updated on PCR: 2017-03-23 23:54:34