Resource Summary

Clinical Question:
What are the benefits and risks of ondansetron for nausea and vomiting of pregnancy?
Bottom Line:
Ondansetron may reduce nausea or vomiting of pregnancy by 25% for one in two users^ compared to doxylamine/pyridoxine. There is real uncertainty if ondansetron in pregnancy is associated with any risk to the fetus. Some observational studies suggesting congenital or cardiac defects may be increased by as much as 1% but these are inconsistent and not supported by better evidence.

Publication Date: 2017-7-24
Last Updated on PCR: 2017-07-26 08:15:53