Resource Summary

Clinical Question:
What are the risks and benefits of opioids for neuropathic pain?
Bottom Line:
Compared to placebo^ high-dose opioids moderately (at least 30%) reduce pain for an additional 1 in every 5-8 people over 4-12 weeks. Opioid-related adverse events lead to discontinuation for 1 in every 11-12 people over placebo. Other medications (like tricyclic antidepressants^ gabapentin/pregabalin^ and duloxetine) are similarly effective with less adverse events. Opioids should only be considered in patients with refractory pain after multiple therapeutic trials.

Publication Date: 2018-6-18
Last Updated on PCR: 2018-06-20 06:25:19