Resource Summary

Clinical Question:
Is sacubitril/valsartan (Entresto®) effective for systolic heart failure (HF)?
Bottom Line:
Based on one randomized controlled trial (RCT)^ for every 36 patients with heart failure switched from ACE inhibitors to sacubitril/valsartan^ one fewer will die and one fewer will be admitted for heart failure over 27 months. Beta-blockers and aldosterone antagonists should be offered first and continued concurrently.

Publication Date: 2017-7-10
Last Updated on PCR: 2017-07-11 07:09:18